Experimental Investigations on Bone Density of the Mandible and Spine in Ovariectomized Rats
نویسنده
چکیده
The aim of this study was to estimate a bone density of the mandible and spine in experimental model of postmenopausal osteoporosis. Female Wistar rats were the investigative material. Rats were qualified for following groups: CL control, SH sham operated, OV after ovariectomy, OVH after ovariectomy receiving 17β-estradiol in three different doses (1.25, 12.5, 125 μg) during seven weeks. After the end of the experiment densitometric examinations of the mandible and spine were made using DEXA method and measured bone mineral density (BMD). The results of the examination indicate that estrogen deficiency after ovariectomy leads to a decrease in BMD index of the examined bones, whereas the administering of 17β-estradiol influences the bone density and depends on hormone dose.
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